Association of multimorbidity patterns and order of physical frailty and cognitive impairment occurrence: a prospective cohort study.

ABSTRACT:

Background

Chronic conditions often co-occur in specific disease patterns. Certain chronic diseases contribute to incident frailty or cognitive impairment (CI), but the associations of multimorbidity patterns and the order of frailty and CI occurrence remain unclear.

Objectives

To determine multimorbidity patterns amongst older adults and their associations with the order of frailty and CI occurrence.

Design

Prospective cohort study.

Methods

Using data from National Health and Aging Trends Study, 7522 community-dwelling participants were included and followed up for four years. Latent class analysis was conducted to identify multimorbidity patterns with clinical meaningfulness. Fine and Grey competing risks models were used to examine the associations between m

SUBMITTER: Wang S 

PROVIDER: S-EPMC12014529 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature