Hydroxysafflor yellow A for ischemic heart diseases: a systematic review and meta-analysis of animal experiments.

ABSTRACT:

Background

Hydroxysafflor yellow A (HSYA) possesses a variety of pharmacological activities which has been demonstrated to be effective against ischemic heart disease (IHD). This study aimed to comprehensively examine the efficacy and summarize the potential mechanisms of HSYA against IHD in animal models.

Methods

We conducted electronic searches for preclinical studies on PubMed, Embase, Web of Science, Cochrane Library, CNKI, SinoMed, Wanfang, and Chinese VIP databases from inception to 31 January 2024. The CAMARADES checklist was chosen to assess the quality of evidence. STATA 14.0 software was utilized to analyze the data. The underlying mechanisms were categorized and summarized.

Results

Twenty-eight studies involving 686 rodents were included and the mean score

SUBMITTER: Mao T 

PROVIDER: S-EPMC12014549 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature