The biological function and prognostic significance of ferroptosis-related genes in clear cell renal cell carcinoma.

ABSTRACT:

Background

Ferroptosis-related genes are essential in cancer development. However, the specific roles of ferroptosis-related genes in clear cell renal cell carcinoma (ccRCC) remain largely unexplored. This study aims to elucidate the biological functions and potential therapeutic implications of ferroptosis-related genes in ccRCC.

Methods

A model integrating the Cancer Genome Atlas (TCGA) database and the GEO dataset was established based on ferroptosis-related genes and clinical data. To determine the proliferative function of ferroptosis-related genes in ccRCC cells, CCK-8 kit assays and colony formation experiments were conducted. Additionally, wound-healing experiments were performed to evaluate the migratory capabilities of these cells.

Results

We identified eigh

SUBMITTER: Ye H 

PROVIDER: S-EPMC12014568 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature