Advanced glycation end-product intake predicts insulin resistance in a sex-dependent fashion.

ABSTRACT:

Purpose

Dietary advanced glycation end products (AGEs) have been implicated in promoting insulin resistance. However, their impact on insulin resistance in a mixed population made up of males and females remains controversial. The aim of this study was to evaluate whether the relationship between dietary AGEs and insulin resistance may be sex-dependent.

Methods

195 males and 239 females were included in this cross-sectional study. Study participants underwent anthropometric and metabolic assessments. AGE intake was estimated using food frequency questionnaires and databases reporting AGE content in individual food items. The relationship between AGE intake and insulin resistance, estimated using HOMA-IR, was assessed using Pearson correlation test. The predictive power of di

SUBMITTER: Sergi D 

PROVIDER: S-EPMC12014793 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature