Imaging biomarkers of cortical neurodegeneration underlying cognitive impairment in Parkinson's disease.

ABSTRACT:

Purpose

Imaging biomarkers bear great promise for improving the diagnosis and prognosis of cognitive impairment in Parkinson's disease (PD). We compared the ability of three commonly used neuroimaging modalities to detect cortical changes in PD patients with mild cognitive impairment (PD-MCI) and dementia (PDD).

Methods

53 cognitively normal PD patients (PD-CN), 32 PD-MCI, and 35 PDD underwent concurrent structural MRI (sMRI), diffusion-weighted MRI (dMRI), and [¹⁸F]FDG PET. We extracted grey matter volumes (sMRI), mean diffusivity (MD, dMRI), and standardized uptake value ratios ([¹⁸F]FDG PET) for 52 cortical regions included in a neuroanatomical atlas. We assessed group differences using ANCOVA models and further applied a cross-validated machine lear

SUBMITTER: Silva-Rodriguez J 

PROVIDER: S-EPMC12014801 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature