An ²¹¹At-labeled alpha-melanocyte stimulating hormone peptide analog for targeted alpha therapy of metastatic melanoma.

ABSTRACT:

Purpose

Patients who develop metastatic melanoma have a very poor prognosis, and new treatments are needed to improve the response rates. Melanocortin-1 receptor (MC1R) is a promising target for radionuclide therapy of metastatic melanoma, and alpha-melanocyte stimulating hormone (α-MSH) peptide analogs show high affinities to MC1Rs. Because targeted alpha therapy (TAT) can be a desirable treatment for metastatic melanoma, this study aimed to develop an ²¹¹At-labeled α-MSH peptide analog for TAT of metastatic melanoma.

Methods

We designed an α-MSH analog labeled with ²¹¹At using a neopentyl glycol scaffold via a hydrophilic linker. Preliminary studies using ¹²⁵I-labeled α-MSH analogs were performed to identify suitable hydrophilic linkers. Th

SUBMITTER: Suzuki H 

PROVIDER: S-EPMC12014842 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature