Identification of Anoikis-Related Genes in Gastric Cancer: Bioinformatics and Experimental Validation.

ABSTRACT:

Introduction

Distant metastasis is the main reason for the poor prognosis of gastric cancer, and anoikis refers to the cell death caused when cells detach from the extracellular matrix or adhere in incorrect locations, playing an important role in the distant metastasis of gastric cancer.

Methods

Download the TCGA-STAD dataset and the anoikis gene set, and filter out the differentially expressed anoikis genes. Perform consensus clustering of gastric cancer samples, and conduct Weighted Gene Correlation Network Analysis (WGCNA), enrichment analysis, and immune infiltration analysis for the expression characteristics of each subtype, while also filtering the genes with differential expression between subtypes. Additionally, through COX survival analysis, identify anoikis genes

SUBMITTER: Song C 

PROVIDER: S-EPMC12014852 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature