Stewart's theory and acid-base changes induced by crystalloid infusion in humans: a randomized physiological trial.

ABSTRACT:

Background

Stewart's acid-base theory states that, under isocapnic conditions, crystalloid infusion affects plasma pH due to changes in strong ion difference and total weak acid concentration: a comprehensive study also assessing renal response and hemodilution effects has not been conducted in humans. We aimed to evaluate Stewart's approach during crystalloid infusion in humans.

Methods

In this randomized trial, patients undergoing surgery with minimal blood losses were randomized to receive to normal saline (chloride content 154 mEq/L, strong ion difference 0 mEq/L), lactated Ringer's (chloride content 112 mEq/L, strong ion difference 29 mEq/L) or Crystalsol (chloride content 98 mEq/L, strong ion difference 50 mEq/L): patients received 10 ml/kg immediately after intubation

SUBMITTER: Dell'Anna AM 

PROVIDER: S-EPMC12014888 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature