Stereological estimation of mean nuclear volume as a prognostic factor in canine subcutaneous mast cell tumors.

ABSTRACT: Classification schemes regarding canine subcutaneous mast cell tumors (csMCTs) remain elusive, lack consensus, and are prone to interobserver variability and bias. This observational study aimed to assess the reproducibility and the prognostic significance of volume-weighted mean nuclear volume (vv¯), a stereological estimation offering insights into nuclear size and its variability, in csMCTs. Thirty csMCTs were selected with information regarding outcome, and vv¯ was estimated using the "point-sampled intercept" method. Interobserver and intraobserver vv¯ reproducibility yielded concordance coefficients near or above 0.90. Regarding previously reported risk factors (pattern, mitotic count, and multinucleated cells), no statistically significant differences were identified between pattern

SUBMITTER: Catarino J 

PROVIDER: S-EPMC12014948 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature