RAB23 facilitates clathrin-coated nascent vesicle formation at the plasma membrane and modulates cell signaling.

ABSTRACT: RAB23 is known to regulate signaling by several growth factors during organogenesis. RABs and other small GTPases function as molecular switches during cellular membrane trafficking. However, what has not been established is how RAB23 functions during cellular membrane trafficking and how this influences cell signaling. To address this, we characterized RAB23's localization in the endocytic pathway and determined the route of endocytosis. We find that RAB23 interacts with β-adaptin (AP2β1) subunit of the clathrin adaptor protein 2 (AP-2) complex, suggesting RAB23's involvement in clathrin-dependent endocytosis at the plasma membrane. Our results show that RAB23 might function at multiple steps during clathrin-coated nascent vesicle formation. We find that RAB23 interacts with clathrin asse

SUBMITTER: Hasan MR 

PROVIDER: S-EPMC12014981 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature