Limitations of genomics to predict and treat autism: a disorder born in the womb.

ABSTRACT: Brain development involves the sequential expression of vulnerable biological processes including cell proliferation, programmed cell death, neuronal migration, synapse and functional unit formation. All these processes involve gene and activity-dependent events that can be distorted by many extrinsic and intrinsic environmental factors, including stress, microbiota, inflammatory signals, hormonal signals and epigenetic factors, hence leading to disorders born in the womb that are manifested later in autism spectrum disorders (ASDs) and other neurodevelopmental disorders. Predicting and treating such disorders call for a conceptual framework that includes all aspects of developmental biology. Here, taking the high incidence of ASDs as an example, we first discuss the intrinsic limitations

SUBMITTER: Ben-Ari Y 

PROVIDER: S-EPMC12015019 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature