Is speech function lateralised in the basal ganglia? Evidence from de novo Parkinson's disease.

ABSTRACT:

Background

Research on the possible influence of lateralised basal ganglia dysfunction on speech in Parkinson's disease is scarce. This study aimed to compare speech in de-novo, drug-naive patients with Parkinson's disease (PD) with asymmetric nigral dopaminergic dysfunction, predominantly in either the right or left hemisphere.

Methods

Acoustic analyses of reading passages were performed. Asymmetry of nigral dysfunction was defined using dopamine transporter-single-photon emission CT (DAT-SPECT).

Results

From a total of 135 de novo patients with PD assessed, 47 patients had a lower right and 36 lower left DAT availability in putamen based on DAT-SPECT. Patients with PD with lower left DAT availability had higher dysarthria severity via composite dysarthria index comp

SUBMITTER: Rusz J 

PROVIDER: S-EPMC12015078 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature