Human iPS cell-derived respiratory organoids as a model for respiratory syncytial virus infection.

ABSTRACT: Respiratory syncytial virus (RSV) is a seasonal respiratory pathogen that primarily affects young children, potentially causing severe lower respiratory tract disease. Despite the high disease burden, understanding of RSV pathophysiology remains limited. To address this, advanced RSV infection models are needed. Whereas HEp-2 cells are widely used because of their high susceptibility to RSV, they do not accurately reflect the host response of the human respiratory tract. In this study, we evaluated human-induced pluripotent stem cell-derived respiratory organoids, which contain respiratory epithelial cells, immune cells, fibroblasts, and vascular endothelial cells, for their potential to model RSV infection and support pharmaceutical research. RSV-infected organoids exhibited high viral ge

SUBMITTER: Hashimoto R 

PROVIDER: S-EPMC12015132 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature