Extensive modulation of the circulating blood proteome by hormonal contraceptive use across two population studies.

ABSTRACT:

Background

The study of circulating blood proteins in population cohorts offers new avenues to explore lifestyle-related and genetic influences describing and shaping human health.

Methods

Utilizing high-throughput mass spectrometry, we quantified 148 highly abundant proteins, functioning in the innate and adaptive immune system, coagulation and nutrient transport in 3632 blood plasma, and 500 serum samples from the CHRIS and BASE-II cross-sectional population studies, respectively. Through multiple regression analyses, we aimed to identify the main factors influencing the circulating proteome at population level.

Results

Many demographic covariates and common medications affect the concentration of high-abundant plasma proteins, but the most significant changes are l

SUBMITTER: Dordevic N 

PROVIDER: S-EPMC12015301 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature