Periostin-mediated activation of NF-κB signaling promotes tumor progression and chemoresistance in glioblastoma.

ABSTRACT: Glioblastoma (GBM) is the most aggressive form of diffuse glioma, characterized by high lethality. Temozolomide (TMZ)-based chemotherapy is a standard treatment for GBM, but development of chemoresistance poses a significant therapeutic challenge. Despite advances in understanding GBM biology, the mechanisms driving TMZ resistance remain unclear. Identifying vital molecular players involved in this resistance is crucial for developing new therapies. Our results indicated that periostin (POSTN) was significantly upregulated in GBM cell lines and patient samples, correlating with poorer clinical outcomes. POSTN overexpression enhanced GBM cell proliferation, migration, invasion, and chemoresistance, while lentiviral suppression of POSTN significantly reduced these behaviors. In vivo, biolumi

SUBMITTER: Shang Y 

PROVIDER: S-EPMC12015317 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature