Comprehensive analysis indicates DDX46 as a novel biomarker for the prognosis of lung adenocarcinoma.

ABSTRACT: The expression levels of DEAD-box 46 (DDX46) are elevated in several malignancies; however, the function of DDX46 in lung adenocarcinoma (LUAD), including its expression patterns and functional implications, has not been fully elucidated. The present study primarily explores the potential role and underlying mechanism of DDX46 in the malignant progression of LUAD. The present study analyzed both publicly available databases and clinical specimens to assess DDX46 expression in LUAD and explore its prognostic significance. The findings demonstrated that elevated DDX46 expression was associated with a worse prognosis in patients with LUAD in comparison with a low DDX46 expression. Functional assays, including Cell Counting Kit-8, colony formation, 5-ethynyl-2'-deoxyuridine incorporation, flow

SUBMITTER: Bian T 

PROVIDER: S-EPMC12015377 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature