The Chemistry of Anticancer Mononuclear and N-Bridged Dinuclear 8-Aminoquinoline Half-sandwich Metal Complexes.

ABSTRACT: Piano-stool complexes of ruthenium and other platinum group metals have shown promising preclinical results as anticancer agents, often with alternative modes of action to traditional platinum-based compounds. Quinoline is considered a privileged structure in medicinal chemistry and many complexes with potent anticancer activity have been reported. To assess the effect of incorporating bidentate 8-aminoquinoline-η²N-1,N-8 (AQH) ligands in half-sandwich piano-stool metal complexes of the general formula [M(L)(AQH)Cl]⁺, the respective Ru, Os (L=η⁶-p-cymene), Rh and Ir (L=η⁵-pentamethylcyclopentadienyl) complexes were prepared. Deprotonation of AQH during the reaction gave dinuclear [M(L)(AQ)]₂ ²⁺ complexes with the deprotonate

SUBMITTER: Steel TR 

PROVIDER: S-EPMC12015398 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature