Relative Contribution of Pharmacokinetics and Immune Signatures to Clinical Outcomes in Patients With HIV-associated Cryptococcal Meningitis.

ABSTRACT:

Background

Host immune responses to HIV-associated cryptococcal meningitis are critical in disease outcome. Their interaction with antifungal drug exposure is poorly understood. This study explored associations between immune biomarkers, antifungal drug exposure, and clinical outcomes in HIV-associated cryptococcal meningitis.

Methods

We analyzed serial plasma and cerebrospinal fluid immune biomarkers from 64 participants recruited from the AMBITION-cm trial. We estimated individual-level exposure to amphotericin B, flucytosine, and fluconazole. Associations between immune biomarkers, pharmacokinetic parameters, and clinical outcomes were evaluated.

Results

An inflammatory cerebrospinal fluid response, characterized by coordination between tumor necrosis factor-α, gra

SUBMITTER: Stott KE 

PROVIDER: S-EPMC12015468 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature