Dynamic and Static Functional Gradient in Temporal Lobe Epilepsy With Hippocampal Sclerosis Versus Healthy Controls.

ABSTRACT:

Aims

The gradient captures the continuous transitions in connectivity, representing an intrinsic hierarchical architecture of the brain. Previous works hinted at the dynamics of the gradient but did not verify them. Cognitive impairment is a common comorbidity of temporal lobe epilepsy (TLE). Gradient techniques provide a framework that could promote the understanding of the neural correlations of cognitive decline.

Methods

Thirty patients with TLE and hippocampal sclerosis and 29 matched healthy controls (HC) were investigated with verbal fluency task-based functional MRI and gradient techniques. The correlation between task-based activation/deactivation and healthy gradients, task-based gradients, and dynamic features calculated with sliding window approaches was compared

SUBMITTER: Wang K 

PROVIDER: S-EPMC12015638 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature