Brd9 antagonism induces beige adipocytes in white adipose tissues and protects against diet-induced obesity.

ABSTRACT:

Objective

Thermogenic beige adipocytes emerge in white adipose tissue (WAT) under certain physiological and pathological conditions, leading to increased energy expenditure, insulin sensitivity, and glucose tolerance. The induction of beige adipocyte formation represents a promising therapeutic approach for obesity and associated chronic diseases; however, the mechanisms controlling WAT beiging remain incompletely understood.

Methods

We conducted a genome-wide knockout screening in the white adipose progenitors of mice to identify lineage repressors of beige adipocyte formation. We further investigated the metabolic effects and gene expression alterations upon Brd9 antagonism in obesity mouse models.

Results

An unbiased genetic screen identified the following four lin

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12015651 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature