Semaglutide-induced weight loss improves mitochondrial energy efficiency in skeletal muscle.

ABSTRACT:

Objective

Glucagon-like peptide-1 receptor agonists (e.g., semaglutide) potently induce weight loss, thereby reducing obesity-related complications. However, weight regain occurs when treatment is discontinued. An increase in skeletal muscle oxidative phosphorylation (OXPHOS) efficiency upon diet-mediated weight loss has been described, which may contribute to reduced systemic energy expenditure and weight regain. We set out to determine the unknown effect of semaglutide on muscle OXPHOS efficiency.

Methods

C57BL/6J mice were fed a high-fat diet for 12 weeks before receiving semaglutide or vehicle for 1 or 3 weeks. The rates of ATP production and oxygen (O₂) consumption were measured via high-resolution respirometry and fluorometry to determine OXPHOS efficiency i

SUBMITTER: Choi RH 

PROVIDER: S-EPMC12015655 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature