The role of recurrent somatic mutations that alter conserved m⁶A motifs in human cancer.

ABSTRACT: N⁶-methyladenosine (m⁶A) is the most abundant internal RNA modification in eukaryotes and plays a key role in cellular growth and development. Global changes in cellular methylated RNA and m⁶A-mediated transcript regulation significantly impact oncogenesis. Here, we investigate how recurrent synonymous and non-synonymous somatic mutations abolishing individual canonical methylated m⁶A motifs affect transcript levels and survival of patients with cancer. Moreover, we explore the effect of these mutations on creating de novo m⁶A motifs. To this end, we compared publicly available data on m⁶A sites with mutations reported in The Cancer Genome Atlas (TCGA). We find that mutations disrupting or creating m⁶A moti

SUBMITTER: Artz O 

PROVIDER: S-EPMC12015683 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature