Investigating the impact of trial retractions on the healthcare evidence ecosystem (VITALITY Study I): retrospective cohort study.

ABSTRACT:

Objective

To investigate the impact of retracted trials on the production and use of healthcare evidence in the evidence ecosystem.

Design

Retrospective cohort study based on forward citation searching.

Data sources

Retraction Watch up to 5 November 2024.

Study selection

Randomised controlled trials in humans that were retracted for any reason.

Methods

Forward citation searching via Google Scholar and Scopus was used to identify evidence synthesis research (21 November 2024) that quantitatively incorporated retracted trials. Data were independently extracted by two groups of researchers. The results of meta-analyses were updated after exclusion of the retracted trials. The proportions of meta-analyses that changed direction of the pooled effect and/or th

SUBMITTER: Xu C 

PROVIDER: S-EPMC12015725 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature