Primary Neurolymphomatosis: A Literature Review.

ABSTRACT:

Background

Primary neurolymphomatosis (PNL) is a rare clinical entity resulting from direct lymphomatous infiltration into the peripheral nervous system. Its diagnosis is challenging as the hematological condition is unknown at the onset of neurological symptoms.

Methods

We report two of our own cases and the first extensive review of published cases of PNL to delineate its clinical features, paraclinical investigation results, progression, and treatment response more precisely. We extracted demographic data, clinical presentation, results of the investigations performed, type and number of treatments, overall survival, and progression-free survival.

Results

We describe 301 cases of PNL in patients with a mean age of 57.9 years, 61% of whom were men. The most common c

SUBMITTER: Chakroun S 

PROVIDER: S-EPMC12015973 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature