The Effect of Severe Sepsis and Septic Shock Management Bundle (SEP-1) Compliance and Implementation on Mortality Among Patients With Sepsis : A Systematic Review.

ABSTRACT:

Background

The Centers for Medicare & Medicaid Services (CMS) Severe Sepsis and Septic Shock Management Bundle (SEP-1) is now included in the Hospital Value-Based Purchasing (VBP) Program.

Purpose

To assess the evidence supporting SEP-1 compliance or SEP-1 implementation in improving sepsis mortality.

Data sources

PubMed, Web of Science, EMBASE, CINAHL Complete, and Cochrane Library from inception to 26 November 2024.

Study selection

Studies of adults with sepsis that included 3- or 6-hour sepsis bundles defined by SEP-1 specifications.

Data extraction

Article screening, full-text review, data extraction, and risk-of-bias assessment were independently performed by 2 authors. Level of evidence was determined using GRADE (Grading of Recommendations Assessm

SUBMITTER: Ford JS 

PROVIDER: S-EPMC12015987 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature