MSIsensor-RNA: Microsatellite Instability Detection for Bulk and Single-cell Gene Expression Data.

ABSTRACT: Microsatellite instability (MSI) is an indispensable biomarker in cancer immunotherapy. Currently, MSI scoring methods by high-throughput omics methods have gained popularity and demonstrated better performance than the gold standard method for MSI detection. However, the MSI detection method on expression data, especially single-cell expression data, is still lacking, limiting the scope of clinical application and prohibiting the investigation of MSI at a single-cell level. Herein, we developed MSIsensor-RNA, an accurate, robust, adaptable, and standalone software to detect MSI status based on expression values of MSI-associated genes. We demonstrated the favorable performance and promise of MSIsensor-RNA in both bulk and single-cell gene expression data in multiplatform technologies incl

SUBMITTER: Jia P 

PROVIDER: S-EPMC12016039 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature