An <i>in vivo</i> systemic massively parallel platform for deciphering animal tissue-specific regulatory function.

ABSTRACT: Introduction: Transcriptional regulation is an important process wherein non-protein coding enhancer sequences play a key role in determining cell type identity and phenotypic diversity. In neural tissue, these gene regulatory processes are crucial for coordinating a plethora of interconnected and regionally specialized cell types, ensuring their synchronized activity in generating behavior. Recognizing the intricate interplay of gene regulatory processes in the brain is imperative, as mounting evidence links neurodevelopment and neurological disorders to non-coding genome regions. While genome-wide association studies are swiftly identifying non-coding human disease-associated loci, decoding regulatory mechanisms is challenging due to causal variant ambiguity and their specific tis

SUBMITTER: Brown AR 

PROVIDER: S-EPMC12016043 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature