Temporal relationship between chronic inflammation and insulin resistance and their combined cumulative effect on cancer risk: a longitudinal cohort study.

ABSTRACT:

Background

Cancer, a chronic and dangerous disease, poses a major public health burden. Inflammation and insulin resistance promote tumorigenesis. However, the temporal relationship between the two and their relationship with cancer risk must be elucidated.

Objective

This study aimed to investigate the association between chronic inflammation, insulin resistance, and the propensity for cancer incidence.

Methods

We explored the temporal relationship between triglyceride index (TyG) and high-sensitivity C-reactive protein (hsCRP) levels using cross-lagged modeling. We used COX proportional risk regression modeling to explore the association between high cumulative triglyceride and glucose index (CumTyG) and high cumulative high-sensitivity C-reactive Protein (CumhsCRP)

SUBMITTER: Zheng X 

PROVIDER: S-EPMC12016061 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature