RBR3, a member of the retinoblastoma-related family from maize, is regulated by the RBR1/E2F pathway.

ABSTRACT: Retinoblastoma-related (RBR) proteins regulate cell division in higher eukaryotes by controlling the adenovirus E2 promoter binding factor (E2F)/dimerization partner (DP) family of transcription factors that regulate expression of many genes involved in cell-cycle progression. We identified a previously undescribed member of the maize RBR family, RBR3, which has the characteristic structure and binding activities of pocket proteins, where interaction depends on a LxCxE motif in the partner proteins and a critical cysteine within the B pocket domain. Like other RBR proteins, RBR3 appears to be regulated by phosphorylation mediated by cyclin-dependent kinases. During endosperm development, RBR3 expression is restricted to the mitotic stage preceding the onset of endoreduplication. This findi

SUBMITTER: Sabelli PA 

PROVIDER: S-EPMC1201608 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature