Potential association between allergic disease and risk of Alzheimer's disease: insight from genetic analysis.

ABSTRACT:

Backgroud

Numerous evidence from observational studies indicated an association between allergic diseases and Alzheimer's Disease (AD). However, the causal association of this relationship remains unclear. To address this, we conducted a two-sample bidirectional Mendelian randomization (MR) analysis to investigate the potential causal impact of allergic diseases on AD.

Methods

We used summary statistics for allergic diseases (allergic rhinitis, asthma, and atopic dermatitis) and AD from comprehensive genome-wide association studies (GWASs). Our primary analytical approach was inverse variance weighted (IVW) method, complemented by MR-Egger method and weighted median (WM) method.

Results

In the forward MR analysis, our results indicate that age of onset of asthma is a

SUBMITTER: Jin T 

PROVIDER: S-EPMC12016102 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature