Clonal hematopoiesis of indeterminate potential and risk of autoimmune thyroid disease.

ABSTRACT:

Background

Autoimmune thyroid disease (AITD) is the most common organ-specific autoimmune disease, often remaining asymptomatic until the thyroid is significantly affected. Clonal hematopoiesis of indeterminate potential (CHIP) has been reported to drive many inflammatory diseases and autoimmune diseases. The association between CHIP and AITD is scarcely reported. This study aims to investigate whether CHIP is associated with the risk of AITD.

Methods

We conducted a prospective community-based cohort study at the UK Biobank. CHIP, defined as the exposure, was identified using whole-exome sequencing (WES) data. AITD was sourced from the inpatient hospitalization register, the death register, and the primary healthcare register. Cox regression models were utilized to estimate

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12016128 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature