Long-term impact of anthracycline in early-stage breast cancer, bridging of MiRNAs profiler for early cardiotoxicity.

ABSTRACT:

Background

Anthracyclines are essential in early breast cancer chemotherapy but pose long-term cardiotoxicity risks.

Objectives

This study aims to investigate the long-term incidence of cancer therapy-related cardiac dysfunction (CTRCD), bridging with the miRNAs profiler representing acute cardiac injury.

Methods

We conducted a prospective cohort including stage I-III breast cancer patients who received anthracycline between 2007 and 2012. Echocardiography was performed before and 12 weeks after anthracycline administration. The miRNAs profiler was conducted by NanoString and RT-PCR. Long-term cardiac magnetic resonance imaging (CMR) was evaluated in 24.2% of asymptomatic participants.

Results

At a median follow-up of 11 [IQR 6-12] years, 194 patients who compl

SUBMITTER: Poovorawan N 

PROVIDER: S-EPMC12016148 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature