Bidirectional Mendelian randomization reveals associations between telomere length and autoimmune diseases.

ABSTRACT:

Background

Autoimmune diseases are a group of complex chronic illnesses that affect multiple organs or body systems. These diseases are characterized by tissue damage, impaired organ function, and increased risk of malignancies, and elevated mortality. Nevertheless, the casual correlation between autoimmune diseases and telomere length remains uncertain.

Objective

Our bidirectional Mendelian randomization analysis was aimed to evaluate the causal association between autoimmune diseases and telomere length.

Methods

To minimize bias, four demographic factors including body mass index (BMI), alcohol consumption, smoking, and income were assessed using two-sample Mendelian randomization analysis. Furthermore, this analysis was conducted to explore the causal relationships

SUBMITTER: Jiang Q 

PROVIDER: S-EPMC12016173 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature