Effects of sugammadex on coagulation: a systematic review and meta-analysis.

ABSTRACT:

Background

Sugammadex, an innovative agent that rapidly and completely reverses rocuronium-induced neuromuscular blockade, may prolong coagulation time and influence postoperative bleeding. This study aimed to investigate the effects of sugammadex on coagulation parameters.

Methods

Cochrane Central Register of Controlled Trials, Embase, and PubMed were searched on September 25, 2024, for randomized control trials (RCTs) examining the impact of sugammadex on coagulation time.

Results

Five RCTs involving 1328 participants were included. Four RCTs with 1302 participants provided data for the meta-analysis. Sugammadex was found to prolong prothrombin time (PT) without affecting activated partial thromboplastin time (APTT).

Conclusions

Sugammadex administration may

SUBMITTER: Tsai YH 

PROVIDER: S-EPMC12016206 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature