Abnormal phosphorylation of human LRH1 at Ser510 predicts poor prognosis and promotes cell viability in lung squamous cell carcinoma.

ABSTRACT: The nuclear receptor liver receptor homolog 1 (LRH1)/NR5A2 is aberrantly expressed in diverse cancer types, including liver and lung cancers. Since we previously showed that excessive phosphorylation of human LRH1 at S510 (hLRH1^pS510-high) is predictable of hepatocellular carcinoma recurrence, we here clarified the clinicopathological and biological significance of hLRH1^pS510-high in lung cancer. By immunohistochemistry using an anti-hLRH1^pS510 monoclonal antibody, we evaluated the hLRH1^pS510 signals in 151 and 150 cases of lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) tissues, respectively, and performed clinicopathological analysis. hLRH1^pS510 was localized in the nucleus of tumor cells in LUAD and LUSC tissues w

SUBMITTER: Mine H 

PROVIDER: S-EPMC12016208 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature