MiR-29a-3p/<i>Vegfa</i> axis modulates high phosphate-induced vascular smooth muscle cell calcification.

ABSTRACT: Vascular calcification (VC) is a major contributor to the progression of cardiovascular disease (CVD). The VC is characterized by arterial stiffness and impaired blood flow. This pathology is especially prevalent in chronic kidney disease (CKD), where dysregulated mineral metabolism and elevated phosphate levels accelerate calcification of vascular smooth muscle cells (VSMCs). Emerging evidence suggests that microRNAs (miRNAs) are key regulators of VC, with the miR-29 family implicated in extracellular matrix remodeling and calcification. We investigated the role of the miR-29a-3p/vascular endothelial growth factor A (Vegfa) axis in CKD-associated VC. Dual-luciferase assays and bioinformatic analysis confirmed that miR-29a-3p directly targets Vegfa, a critical regulator of va

SUBMITTER: Fu C 

PROVIDER: S-EPMC12016250 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature