Early experience with proton craniospinal irradiation in adult patients with leptomeningeal disease.

ABSTRACT:

Background

Leptomeningeal disease (LMD) is a fatal complication of cancer linked to poor survival rates and limited treatment options. While photon involved-field radiotherapy is the standard of care for local palliation and symptom alleviation, it lacks durable disease control. Recent data suggest proton craniospinal irradiation (pCSI) to be a promising treatment option, potentially prolonging progression-free survival (PFS) and overall survival (OS). Herein, we report our initial experience with pCSI for treating LMD from solid malignancies.

Methods

Adult patients treated with pCSI for LMD were identified, with analysis of patient, tumor, and treatment characteristics as well as clinical outcomes.

Results

Nine patients were eligible for analysis who were treated bet

SUBMITTER: Ehret F 

PROVIDER: S-EPMC12016269 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature