Structural features of somatic and germline retrotransposition events in humans.

ABSTRACT:

Background

Transposons are DNA sequences able to move or copy themselves to other genomic locations leading to insertional mutagenesis. Although transposon-derived sequences account for half of the human genome, most elements are no longer transposition competent. Moreover, transposons are normally repressed through epigenetic silencing in healthy adult tissues but become derepressed in several human cancers, with high activity detected in colorectal cancer. Their impact on non-malignant and malignant tissue as well as the differences between somatic and germline retrotransposition remain poorly understood. With new sequencing technologies, including long read sequencing, we can access intricacies of retrotransposition, such as insertion sequence details and nested repeats, that ha

SUBMITTER: Nummi P 

PROVIDER: S-EPMC12016303 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature