Assessing the causal effects of type 2 diabetes and obesity-related traits on COVID-19 severity.

ABSTRACT:

Background

Type 2 diabetes (T2D) and obesity-related traits are highly comorbid with coronavirus disease 2019 (COVID-19), but their causal relationships with disease severity remain unclear. While recent Mendelian randomization (MR) studies suggest a causal link between obesity-related traits and COVID-19 severity, findings regarding T2D are inconsistent, particularly when adjusting for body mass index (BMI). This study aims to clarify these relationships.

Methods

We applied various MR methods to assess the causal effects of BMI-adjusted T2D (T2DadjBMI) and obesity-related traits (BMI, waist circumference, and waist-hip ratio) on COVID-19 severity. Genetic instruments were obtained from large-scale genome-wide association studies (GWAS), including 898K participants for T2D a

SUBMITTER: Seo J 

PROVIDER: S-EPMC12016339 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature