The role of androgens and global and tissue-specific androgen receptor expression on body composition, exercise adaptation, and performance.

ABSTRACT: Gonadal testosterone stimulates skeletal muscle anabolism and contributes to sexually differentiated adipose distribution through incompletely understood mechanisms. Observations in humans and animal models have indicated a major role for androgen receptor (AR) in mediating sex differences in body composition throughout the lifespan. Traditional surgical, genetic and pharmacological studies have tested systemic actions of circulating androgens, and more recent transgenic approaches have allowed for tests of AR gene function in specific androgen responsive niches contributing to body composition, including: skeletal muscle and surrounding interstitial cells, white and brown adipose, as well as trabecular and cortical bone. Less well understood is how these functions of gonadal androgens int

SUBMITTER: Barsky ST 

PROVIDER: S-EPMC12016402 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature