Optimizing midlife metabolic syndrome thresholds for dementia: a prospective study of two UK population-based cohorts.

ABSTRACT:

Background

The concept of metabolic syndrome (MetS) was developed to identify individuals at higher risk of type 2 diabetes and cardiovascular disease, but its relevance for dementia remains unclear. We examined MetS in midlife for association with late-onset dementia, focusing on the thresholds of MetS components that carry risk for dementia.

Methods

MetS components (waist circumference, blood pressure, triglycerides, HDL-C, and fasting glucose) were measured on 6,137 white participants < 60 years from the Whitehall II (WII) cohort study. A changepoint method in time-to-event analyses was used to identify optimal thresholds, and those exhibiting better performance for dementia were retained to develop a revised MetS definition. Results were validated on 171,886 participants

SUBMITTER: Vidil S 

PROVIDER: S-EPMC12016442 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature