An updated comparison of microarray and RNA-seq for concentration response transcriptomic study: case studies with two cannabinoids, cannabichromene and cannabinol.

ABSTRACT:

Background

Transcriptomic benchmark concentration (BMC) modeling provides quantitative toxicogenomic information that is increasingly being used in regulatory risk assessment of data poor chemicals. Over the past decade, RNA sequencing (RNA-seq) is gradually replacing microarray as the major platform for transcriptomic applications due to its higher precision, wider dynamic range, and capability of detecting novel transcripts. However, it is unclear whether RNA-seq offers substantial advantages over microarray for concentration response transcriptomic studies.

Results

We provide an updated comparison between microarray and RNA-seq using two cannabinoids, cannabichromene (CBC) and cannabinol (CBN), as case studies. The two platforms revealed similar overall gene expression pa

SUBMITTER: Gao X 

PROVIDER: S-EPMC12016467 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature