A dynamic protein interactome drives energy conservation and electron flux in <i>Thermococcus kodakarensis</i>.

ABSTRACT: Life is supported by energy gains fueled by catabolism of a wide range of substrates, each reliant on the selective partitioning of electrons through redox (reduction and oxidation) reactions. Electron flux through tunable and regulated protein interactions provides dynamic routes for energy conservation, but how electron flux is regulated in vivo, particularly for archaeal metabolisms that support rapid growth at the thermodynamic limits of life, is poorly understood. Identification of bona fide in vivo protein assemblies and how such assemblies dictate the totality of electron flux is critical to our understanding of the regulation imposed on metabolism, energy production, and energy conservation. Here, 25 key proteins in central metabolic redox pathways in th

SUBMITTER: Williams SA 

PROVIDER: S-EPMC12016516 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature