Role of the TPR family protein VPA1365 in regulating type III secretion system 2 and virulence in <i>Vibrio parahaemolyticus</i>.

ABSTRACT: Vibrio parahaemolyticus is a notable seafood-borne pathogen capable of colonizing the intestines of hosts and inducing acute gastroenteritis. The intestinal colonization and enterotoxicity of V. parahaemolyticus are highly reliant on the type III secretion system 2 (T3SS2), encoded within the pathogenicity island (Vp-PAI). The expression of Vp-PAI is strictly regulated by bile acid signals and transcriptional regulators VtrA/VtrB. In this study, we identified a tetratricopeptide repeat (TPR) family protein named VPA1365, which regulates the expression of T3SS2 and is indispensable for the intestinal colonization of V. parahaemolyticus. The expression and secretion of the T3SS2-dependent protein VopD2 were significantly reduced in Δvpa1365 compared to that of the

SUBMITTER: Yin W 

PROVIDER: S-EPMC12016518 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature