Prediction of primary biliary cholangitis among health check-up population with anti-mitochondrial M2 antibody positive.

ABSTRACT:

Backgrounds/aims

Anti-mitochondrial M2 antibody (AMA-M2) is a specific marker for primary biliary cholangitis (PBC) and it could be also present in non-PBC individuals.

Methods

A total of 72,173 Chinese health check-up individuals tested AMA-M2, of which non-PBC AMA-M2 positive individuals were performed follow-up. Baseline data of both clinical characteristics and laboratory examinations were collected in all AMA-M2-positive individuals. Least absolute shrinkage and selection operator (LASSO) regression was performed to investigate the potential variables for developing PBC.

Results

A total of 2,333 individuals were positive with AMA-M2. Eighty-two individuals had a medical history of PBC or fulfilled the diagnostic criteria of PBC at baseline, and 2,076 individuals

SUBMITTER: Li H 

PROVIDER: S-EPMC12016612 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature