Clinical Impact of Microbiome Characteristics in Treatment-Naive Extranodal NK/T-Cell Lymphoma Patients.

ABSTRACT:

Purpose

Extranodal natural killer/T-cell lymphoma (ENKTL) predominantly manifests in East Asia and Latin America. Despite shared intrinsic factors, such as ethnic and genetic backgrounds, the progression of ENKTL can be influenced by extrinsic factors related to changing lifestyle patterns.

Materials and methods

This study collected stool samples from newly diagnosed (ND)-ENKTL patients (n=40) and conducted whole genome shotgun sequencing.

Results

ND-ENKTL revealed reduced alpha diversity in ND-ENKTL compared to healthy controls (HCs) (p=0.008), with Enterobacteriaceae abundance significantly contributing to the beta diversity difference between ENKTL and HCs (p < 0.001). Functional analysis indicated upregulated aerobic metabolism and degradation of aromatic compound

SUBMITTER: Yoon SE 

PROVIDER: S-EPMC12016819 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature