Survival of Children with Acute Lymphoblastic Leukemia with Risk Group-Based Protocol Changes: A Single-Center Experience with 460 Patients over a 20-Year Period.

ABSTRACT:

Purpose

Recent treatments for pediatric acute lymphoblastic leukemia (ALL) are founded on risk stratification. We examined the survival rates and prognostic factors of patients over a 20-year period at a single institution.

Materials and methods

This study analyzed patients diagnosed with ALL and treated at the Pediatric Department of Samsung Medical Center (SMC). Patients were categorized into standard-risk (SR), high-risk (HR), and very high-risk (VHR) groups. The SMC protocol for the HR group underwent two changes during the study period: a modified Children's Cancer Group (CCG)-1882 protocol was used from 2000 to 2005, the Korean multicenter HR ALL-0601 protocol from 2006 to 2014, and the Korean multicenter HR ALL-1501 protocol from 2015 to 2019.

Results

Of the 46

SUBMITTER: Lee NH 

PROVIDER: S-EPMC12016849 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature