A comprehensive transcriptome based meta-analysis to unveil the aggression nexus of oral squamous cell carcinoma.

ABSTRACT: Lymph node metastasis in oral cancer (OC) complicates management due to its aggressive nature and high risk of recurrence, underscoring the need for biomarkers for early detection and targeted therapies. However, the drivers of this aggressive phenotype remain unclear due to the variability in gene expression patterns. To address this, an integrative meta-analysis of six publicly available transcriptomic profiles, categorized by lymph nodal status, is conducted. Key determinants of disease progression are identified through functional characterization and the TopConfects ranking approach of nodal associated differentially expressed genes (DEGs). To explore the critical nexus between lymph node metastasis and OC recurrence, significant metastatic genes were cross-analysed with literature-de

SUBMITTER: Vastrad SJ 

PROVIDER: S-EPMC12016861 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature