The inflammaging microenvironment induces dysfunctional rewiring of Tfh cell differentiation.

ABSTRACT: Humoral immunity is orchestrated by follicular helper T (Tfh) cells, which promote cognate B cells to produce high-affinity, protective antibodies. In aged individuals, humoral immunity after vaccination is diminished despite the presence of Tfh cells, suggesting defects after initial Tfh cell formation. In this study, we utilized both murine and human systems to investigate how aging alters Tfh cell differentiation after influenza vaccination. We found that young Tfh cells underwent progressive differentiation after influenza vaccination, culminating in clonal expansion of effector-like cells in both draining lymph nodes and blood. In aging, early stages of Tfh cell development occurred normally. However, aging rewired the later stages of development in Tfh cells, resulting in a transcrip

SUBMITTER: Nelson CS 

PROVIDER: S-EPMC12016926 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature