A New Porcine Reproductive and Respiratory Syndrome Virus with <i>N</i>-Linked Glycosylation Site Deletion in GP5 44th Amino Acid from JXA1, NADC30-Like, and JM Triparental Recombination.

ABSTRACT: Porcine reproductive and respiratory syndrome virus (PRRSV) is a significant pathogen causing substantial financial losses in the global swine industry. The prevention of PRRSV is hampered due to frequent gene recombination among different strains of PRRSV. In this study, a new PRRSV strain, PRRSV-HQ-2020, was identified from nursery piglets in Yunnan Province, China, in 2020. The complete genome analysis revealed that PRRSV-HQ-2020 is highly similar to JXA1-like (lineage 8.7 PRRSV, isolated from China in 2008) in the 5'UTR, nsp1-9, and nsp11 coding regions. Additionally, it has a resemblance to JM (lineage 3 PRRSV, isolated from Taiwan, China, in 2010) in the nsp12-M coding region and NADC30 (lineage 1.8 PRRSV, isolated from North American in 2008) in the nsp10, N, and 3'UTR, suggesting a

SUBMITTER: Zhou X 

PROVIDER: S-EPMC12016986 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature